Pharmacokinetics
After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. Absolute bioavailability is high – up to 90%. Therapeutic concentration is reached 30 minutes after ingestion. Cmax after taking a dose of 8 mg is observed at the 2nd hour and is 1.2 mg / ml.
T1 / 2 – 5 hours. After repeated administration, an equilibrium concentration is established.
To a small extent, it binds to blood proteins. Easily passes through the blood-brain barrier. To a small extent (about 10%) it is metabolized in the liver by demethylation.
It is excreted (in unchanged form and in the form of metabolites), mainly with urine (up to 74%). Renal clearance is approximately 100 ml/min.
In patients with Alzheimer’s disease, the plasma concentration of galantamine may increase. With moderate and severe impairment of liver and kidney function, plasma concentrations of galantamine increase.
Dosage
Inside, during meals, drinking water.
Adults:
The daily dose is 8-32 mg, divided into 2-4 doses.
With myasthenia gravis, the daily dose is divided into 3 doses.
In Alzheimer’s disease, treatment is recommended to start with taking 4 mg tablets 2 times / day. Within 4 weeks, the daily dose can be gradually increased to 16 mg – 1 tab., 8 mg 2 times / day – in the morning and in the evening. During treatment with the drug, it is necessary to ensure the intake of a sufficient amount of liquid. If during treatment it is necessary to stop taking the drug, then the restoration of treatment should begin with the lowest dose and gradually increase it.
Patients with moderate hepatic and renal impairment:
The initial dose is 4 mg 1 time / day, which is taken in the morning, for at least 1 week, after which the dose is increased to 4 mg 2 times / day and taken for 4 weeks.
The total daily dose should not exceed 12 mg.
Top products, popular medicines, medicines from Europe, medicines from the Czech Republic, Germany, Poland
Buy Galantamine Armran.com
Price Galantamine Armran.com
Цена Galantamine Armran.com
Купить Galantamine Armran.com
