INDICATIONS NEURONTIN Alzheimer’s disease from mild to severe forms.
USE OF NEURONTIN Treatment should be started and carried out under the supervision of a physician. Therapy should only be started if there is a guardian who will regularly monitor the patient’s intake of the drug. Tablets should be taken 1 time per day at the same time every day. Tablets can be taken with or without food. Adults. The maximum daily dose is 20 mg. In order to reduce the risk of adverse reactions, the maintenance dose should be determined by gradually increasing the dose by 5 mg per week during the first 3 weeks as follows: 1st week (1-7th day): take ½ tablet (5 mg per day) during the week; 2nd week (8-14th day): take 1 tablet (10 mg per day) for a week; Week 3 (Days 15-21): Take 1½ tablets (15 mg per day) for a week; starting from the 4th week: take 2 tablets (20 mg per day) every day. The recommended maintenance dose is 20 mg per day. The duration of treatment is individually determined by a doctor who has experience in diagnosing and treating Alzheimer’s disease. Tolerability and dosing of memantine should be regularly assessed, preferably within three months of starting treatment. In the future, the clinical effect of memantine and the patient’s response to treatment should be evaluated regularly in accordance with current clinical guidelines. Maintenance treatment can be continued as long as the therapeutic effect remains favorable and memantine is well tolerated by the patient. Consideration should be given to discontinuing treatment with memantine if signs of a therapeutic effect disappear or the patient’s tolerance to treatment worsens. Elderly patients. Based on the results of clinical studies, the recommended dose for patients over the age of 65 years is 20 mg per day (2 tablets of 10 mg 1 time per day), as indicated above. Impaired kidney function. For patients with impaired renal function of mild severity (creatinine clearance 50-80 ml / min), dose reduction is not required. In patients with moderate renal impairment (creatinine clearance 30-49 ml / min), the daily dose should be reduced to 10 mg. The dose can be increased to 20 mg per day according to the standard scheme, if there are no negative reactions after at least 7 days of treatment. In patients with severe renal impairment (creatinine clearance 5-29 ml / min), the daily dose should be reduced to 10 mg. Impaired liver function. For patients with mild to moderate hepatic impairment (Child-Pugh Class A and Class B), dose adjustment is not required. The use of memantine in patients with severe hepatic impairment is not recommended.
CONTRAINDICATIONS hypersensitivity to the active substance or to any component of the drug.
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