Description of the pharmacological action
Alpha-blocker, acting mainly on postsynaptic α1-adrenergic receptors. By blocking α1-adrenergic receptors located in the triangle and sphincter of the bladder, urethra, alfuzosin eliminates spasm of smooth muscle fibers, which leads to a decrease in resistance to urine outflow. Reduces the tone of smooth muscles of arteries and veins. Reduces OPSS and systemic blood pressure.
Indications for use
Treatment of functional manifestations of benign prostatic hyperplasia in the absence of the possibility of surgical intervention, as well as in cases of progressive growth, especially in elderly patients.
Release form
controlled release tablets, film-coated 5 mg; blister pack 10, carton pack 6.
controlled release tablets, film-coated 5 mg; blister pack 10, cardboard box 500.
Pharmacodynamics
Alpha-blocker, acting mainly on postsynaptic α1-adrenergic receptors. By blocking α1-adrenergic receptors located in the triangle and sphincter of the bladder, urethra, alfuzosin eliminates spasm of smooth muscle fibers, which leads to a decrease in resistance to urine outflow. Reduces the tone of smooth muscles of arteries and veins. Reduces OPSS and systemic blood pressure.
Pharmacokinetics
After oral administration, alfuzosin is absorbed from the gastrointestinal tract. Cmax in plasma is reached after 3 hours and is 10.3 ng / ml. The differences between the maximum and minimum plasma concentrations are insignificant. Eating does not affect absorption.
Plasma protein binding is about 90%. Metabolized in the liver. T1 / 2 – 8 hours. 15-30% of inactive metabolites are excreted in the urine, 75-91% – with feces. 11% of alfuzosin is excreted in the urine unchanged.
In patients older than 75 years, there is a higher plasma concentration and bioavailability of alfuzosin (possibly due to a decrease in liver metabolism). In patients with severe renal impairment, there is an increase in the clearance of alfuzosin (possibly due to less binding to plasma proteins).
Use during pregnancy
The drug is not intended for use in women.
Contraindications for use
Hypersensitivity, orthostatic hypotension (history), severe liver dysfunction (Child-Pugh class C), severe renal dysfunction (Cl creatinine <30 ml / min), concomitant use of other alpha-blockers.
Top products, popular medicines, medicines from Europe, medicines from the Czech Republic, Germany, Poland
Buy Alfuzosin Armran.com
Price Alfuzosin Armran.com
Цена Alfuzosin Armran.com
Купить Alfuzosin Armran.com
