pharmachologic effect
Antiparkinsonian drug, dopamine receptor agonist. It is believed that the mechanism of action is associated with the ability of pramipexole to stimulate dopamine receptors in the striatum. This is confirmed by the effect on the level of impulsation in striatal neurons due to the activation of dopamine receptors in the striatum and substantia nigra.
It cannot be ruled out that pramipexole inhibits prolactin secretion in humans.
Indications
Treatment of Parkinson’s disease (in the form of monotherapy and in combination with levodopa).
Dosing regimen
For adults, when taken orally, the initial dose is 375 mcg / day in 3 divided doses. The dose should be increased every 5-7 days until the maximum therapeutic effect is achieved, which is observed when taking 1.5-4.5 mg / day.
In patients with impaired renal function, the initial dose is 125 mcg / day, the frequency of administration is 1-3 times / day, depending on the CC values.
Maximum doses: single dose – 1.5 mg; daily dose with CC more than 60 ml / min – 4.5 mg in 3 doses, with CC 35-59 ml / min – 3 mg in 2 doses, with CC 15-34 ml / min – 1.5 mg in 1 dose.
It is recommended to stop treatment within 1 week.
Side effect
From the side of the central nervous system and peripheral nervous system: drowsiness, dyskinesia, hallucinations; in some cases – insomnia. With a rapid decrease in the dose of pramipexole, as well as with abrupt cancellation, the development of NMS is possible.
From the digestive system: nausea, constipation.
Since the cardiovascular system: in some cases, at the beginning of treatment – arterial hypotension (especially with a gradual increase in dose for too short a time).
Other: in some cases – peripheral edema.
Contraindications
Hypersensitivity to pramipexole.
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