multiple injection of a dose of 60 mcg C max , determined by immunological methods, is detected after 3 hours and is 6-10 IU/ml. With 4 subcutaneous administration of the same dose every 48 hours, moderate accumulation of the drug occurs. After a single dose, intracellular and serum activity of 2-5A synthetase and serum concentrations of beta 2 microglobulin and neopterin (markers of biological response) increase within 24 hours and then decrease within 2 days.
Metabolism and excretion
Interferon beta is metabolized and excreted by the liver and kidneys. The total clearance is about 33-55 l/h.
Clinical pharmacology
Interferon. A drug used for multiple sclerosis.
Indications for use
Treatment of relapsing-remitting multiple sclerosis.
The drug was not effective in patients with secondary progressive multiple sclerosis in the absence of exacerbations.
Contraindications for use
- Severe depressive disorders and/or suicidal ideation;
- epilepsy in the absence of effect from the use of appropriate therapy;
- pregnancy;
- lactation;
- children up to 12 years old;
- hypersensitivity to natural or recombinant interferon beta, to other components of the drug.
