Indications of the drug Madopar®
Parkinson’s disease, including:
- in patients with dysphagia, with akinesia in the early morning hours and in the afternoon, patients with the phenomena of “depletion of the effect of a single dose” or “increase in the latent period until the onset of the clinical effect of the drug” (Madopar® “125” fast-acting tablets (dispersible));
- in patients with any type of fluctuation in the action of levodopa, namely, “peak dose dyskinesia” and “end dose phenomenon”, for example, immobility at night (Madopar® < /span>GSS “125”).
Restless legs syndrome:
- idiopathic restless legs syndrome
- restless legs syndrome in patients with chronic renal failure on dialysis.
Dosing regimen
Treatment should be started gradually, individually selecting doses until the optimal therapeutic effect is achieved.
Madopar capsules® “125” should be swallowed whole without chewing.
Madopar capsules® GSS “125” should be swallowed whole, without chewing; they should not be opened before use to avoid loss of the effect of the modified release of the active substance.
Madopar tablets® “250” can be crushed to make swallowing easier.
Madopar® “125” fast-acting tablets (dispersible) should be dissolved in 25-50 ml of water. The tablet completely dissolves in a few minutes to form a milky-white solution, which should be taken no later than 30 minutes after the tablet dissolves. Since a precipitate can quickly form, it is recommended to stir the solution before use.
Parkinson’s disease
Standard dosing regimen
Orally, at least 30 minutes before or 1 hour after meals.
Initial therapy
At the early stage of Parkinson’s disease, it is recommended to begin treatment with Madopar at a dose of 62.5 mg (50 mg levodopa + 12.5 mg benserazide 3-4 times a day). If well tolerated, the dose should be gradually increased, depending on the patient’s response.
The optimal effect is achieved, as a rule, with a daily dose containing 300-800 mg of levodopa + 75-200 mg of benserazide, taken in 3 or more doses. It may take 4 to 6 weeks to achieve optimal results. Further increases in the daily dose, if necessary, should be carried out at intervals of 1 month.
